TAPASS - Tool for Annotation of Protein Amyloidogenicity in the context of other Structural States

TAPASS pipeline is designed to predict protein aggregation by accounting for the overall structural context of the protein. In particular, the pipeline allows the detection of Exposed Amyloidogenic Regions (EARs) located within intrinsically disordered regions (IDRs) and carrying high amyloidogenic potential.

Citing TAPASS: T. Falgarone, É. Villain, A. Guettaf, J. Leclercq, A. V Kajava, J Struct Biol. (2022) 214(1):107840. doi: 10.1016/j.jsb.2022.107840. Documentation

Paste one protein sequence in FASTA format (Example):

NOTE : Maximum 15000 characters

Options

Amyloidogenic regions :
ArchCandy
Tango
PASTA
Structural domains (CATH)
Protein domains (Pfam)
Transmembrane regions (TMHMM)
Unstructured regions (IUPred and BiSMM predictor)
Tandem repeats (Meta Repeat Finder)

Kingdom:
Short linear motifs (SLiMs)
Signal peptide (SignalP)

Upload PDB file

NOTE : Maximum 5MB.
The file name must contain only alphanumeric characters with the .pdb extension. Example: Q8N9v3.pdb

Options

Amyloidogenic regions :
ArchCandy
Tango
PASTA
Transmembrane regions (TMHMM)

Kingdom:
Short linear motifs (SLiMs)
Signal peptide (SignalP)